About USMDO Exam
About US Medicine & Disease Olympiad
USMDO assesses your understanding of human biology, diseases and medical concepts, along with your ability to apply knowledge to clinical scenarios, interpret data and think like a future medical professional.
USMDO Scoring
There is no negative marking and no points are deducted for unanswered questions.
| USMDO Level | Description |
|---|---|
| Number of Rounds | 1 (Single National Exam) |
| Progression | Top scorers qualify for IMDO |
USMDO Calculator Policy
| Feature | Policy |
|---|---|
| Physical Calculator | Prohibited |
| Digital Calculator | Provided on-screen (if needed) |
| Scratch Paper | Generally allowed (must be shown to the camera if proctored) |
The Exam
You have 2 hours to complete the exam consisting of 160 multiple-choice questions.
Who the USMDO is for
- Grades 9–12: Open to all US high school students
- Olympiad Competitors: The direct pathway to the International Medicine and Disease Olympiad(IMDO).
- Pre-Med Applicants: Students building a competitive profile for top-tier MD, DO or MD/PhD programs.
- Future Medics: Students focused on Physiology, Pathology, and Clinical Medicine rather than general biology.
USMDO SAMPLE QUESTION
A 17-year-old student reports increased thirst, frequent urination, and fatigue. Laboratory findings shows elevated blood glucose, low insulin levels and presence of ketone bodies in urine. Which of the following processes is most directly responsible for the production of ketone bodies in this patient?
- Decreased gluconeogenesis
- Increased glycogen synthesis in liver
- Increased glucose uptake by muscle cells
- Enhanced β-oxidation of fatty acids in liver mitochondria
Answer: 4
Course Curriculum
1 Macromolecules
2 The Structures of the Cell
3 Cell Membrane
4 Passive and Active Transport
5 Metabolism and Enzymes
6 Cellular Respiration
7 Cell Signaling
8 Mitosis
9 Meiosis
10 Mendelian Genetics
11 Chromosomes
12 DNA
13 Replication
14 Transcription
15 Translation
16 Gene Regulation
17 Viruses
18 Bacteria
19 Biotechnology
20 Cell Death
21 Cancer
22 Stem Cells
1 Organization of the Human Body
2 Homeostasis
3 The Digestive System
4 The Circulatory System
5 The Respiratory System
6 The Immune System
7 The Excretory System
8 The Endocrine System
9 The Reproductive System
10 The Nervous System
11 The Muscular System
12 The Skeletal System
13The Integumentary System
1 Cancer
2 Genetic Diseases
3 Cardiovascular Diseases
4 Blood Diseases
5 Lung Diseases
6 Gastrointestinal Diseases
7 Kidney Diseases
8 Reproductive Diseases
9 Skin Diseases
10 Bone and Joint Diseases
11 Muscle Diseases
12 Nervous System Diseases
13 Endocrine System Diseases
14 Immunologic Diseases
15 Infectious Diseases

