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About US Medicine & Disease Olympiad

USMDO assesses your understanding of human biology, diseases and medical concepts, along with your ability to apply knowledge to clinical scenarios, interpret data and think like a future medical professional.

USMDO Scoring

There is no negative marking and no points are deducted for unanswered questions.

USMDO Level Description
Number of Rounds 1 (Single National Exam)
Progression Top scorers qualify for IMDO

USMDO Calculator Policy
Feature Policy
Physical Calculator Prohibited
Digital Calculator Provided on-screen (if needed)
Scratch Paper Generally allowed (must be shown to the camera if proctored)
The Exam

You have 2 hours to complete the exam consisting of 160 multiple-choice questions.


Who the USMDO is for
  1. Grades 9–12: Open to all US high school students
  2. Olympiad Competitors: The direct pathway to the International Medicine and Disease Olympiad(IMDO).
  3. Pre-Med Applicants: Students building a competitive profile for top-tier MD, DO or MD/PhD programs.
  4. Future Medics: Students focused on Physiology, Pathology, and Clinical Medicine rather than general biology.

USMDO SAMPLE QUESTION

A 17-year-old student reports increased thirst, frequent urination, and fatigue. Laboratory findings shows elevated blood glucose, low insulin levels and presence of ketone bodies in urine. Which of the following processes is most directly responsible for the production of ketone bodies in this patient?

  1. Decreased gluconeogenesis
  2. Increased glycogen synthesis in liver
  3. Increased glucose uptake by muscle cells
  4. Enhanced β-oxidation of fatty acids in liver mitochondria

Answer: 4

Course Curriculum

1 Macromolecules

2 The Structures of the Cell

3 Cell Membrane

4 Passive and Active Transport

5 Metabolism and Enzymes

6 Cellular Respiration

7 Cell Signaling

8 Mitosis

9 Meiosis

10 Mendelian Genetics

11 Chromosomes

12 DNA

13 Replication

14 Transcription

15 Translation

16 Gene Regulation

17 Viruses

18 Bacteria

19 Biotechnology

20 Cell Death

21 Cancer

22 Stem Cells

1 Organization of the Human Body

2 Homeostasis

3 The Digestive System

4 The Circulatory System

5 The Respiratory System

6 The Immune System

7 The Excretory System

8 The Endocrine System

9 The Reproductive System

10 The Nervous System

11 The Muscular System

12 The Skeletal System

13The Integumentary System

1 Cancer

2 Genetic Diseases

3 Cardiovascular Diseases

4 Blood Diseases

5 Lung Diseases

6 Gastrointestinal Diseases

7 Kidney Diseases

8 Reproductive Diseases

9 Skin Diseases

10 Bone and Joint Diseases

11 Muscle Diseases

12 Nervous System Diseases

13 Endocrine System Diseases

14 Immunologic Diseases

15 Infectious Diseases